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Mice lacking the gene encoding tissue-type plasminogen activator show a selective interference with late-phase long-term potentiation in both Schaffer collateral and mossy fiber pathways.

The gene encoding tissue-type plasminogen activator (t-PA) is an immediate response gene, downstream from CREB-1 and other constitutively expressed transcription factors, which is induced in the hippocampus during the late phase of long-term potentiation (L-LTP). Mice in which the t-PA gene has been...

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Publicat a:Proc Natl Acad Sci U S A
Autors principals: Huang, Y Y, Bach, M E, Lipp, H P, Zhuo, M, Wolfer, D P, Hawkins, R D, Schoonjans, L, Kandel, E R, Godfraind, J M, Mulligan, R, Collen, D, Carmeliet, P
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 1996
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC38736/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8710934/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.16.8699
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