Plasminogen activator inhibitor-1 gene-deficient mice. I. Generation by homologous recombination and characterization.

Homozygous plasminogen activator inhibitor-1 (PAI-1)-deficient (PAI-1-/-) mice were generated by homologous recombination in D3 embryonic stem cells. Deletion of the genomic sequences encompassing the transcription initiation site and the entire coding regions of murine PAI-1 was demonstrated by Sou...

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Detalhes bibliográficos
Main Authors: Carmeliet, P, Kieckens, L, Schoonjans, L, Ream, B, van Nuffelen, A, Prendergast, G, Cole, M, Bronson, R, Collen, D, Mulligan, R C
Formato: Artigo
Idioma:Inglês
Publicado em: 1993
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC288473/
https://ncbi.nlm.nih.gov/pubmed/8254028
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