Plasminogen activator inhibitor-1 gene-deficient mice. I. Generation by homologous recombination and characterization.

Homozygous plasminogen activator inhibitor-1 (PAI-1)-deficient (PAI-1-/-) mice were generated by homologous recombination in D3 embryonic stem cells. Deletion of the genomic sequences encompassing the transcription initiation site and the entire coding regions of murine PAI-1 was demonstrated by Sou...

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Bibliografiske detaljer

Udgivet i:	J Clin Invest
Principais autores:	Carmeliet, P, Kieckens, L, Schoonjans, L, Ream, B, van Nuffelen, A, Prendergast, G, Cole, M, Bronson, R, Collen, D, Mulligan, R C
Format:	Artigo
Sprog:	Inglês
Udgivet:	American Society for Clinical Investigation 1993
Fag:	Research Article
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC288473/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8254028/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI116892
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