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Ca(2+)-independent Binding of Anionic Phospholipids by Phospholipase C δ1 EF-hand Domain
Recombinant EF-hand domain of phospholipase C δ1 has a moderate affinity for anionic phospholipids in the absence of Ca(2+) that is driven by interactions of cationic and hydrophobic residues in the first EF-hand sequence. This region of PLC δ1 is missing in the crystal structure. The relative orien...
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| Main Authors: | , , , |
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| Formáid: | Artigo |
| Teanga: | Inglês |
| Foilsithe: |
American Society for Biochemistry and Molecular Biology
2013
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| Ábhair: | |
| Rochtain Ar Líne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3873580/ https://ncbi.nlm.nih.gov/pubmed/24235144 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.512186 |
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