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Ca(2+)-independent Binding of Anionic Phospholipids by Phospholipase C δ1 EF-hand Domain

Recombinant EF-hand domain of phospholipase C δ1 has a moderate affinity for anionic phospholipids in the absence of Ca(2+) that is driven by interactions of cationic and hydrophobic residues in the first EF-hand sequence. This region of PLC δ1 is missing in the crystal structure. The relative orien...

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Detalhes bibliográficos
Main Authors: Cai, Jingfei, Guo, Su, Lomasney, Jon W., Roberts, Mary F.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3873580/
https://ncbi.nlm.nih.gov/pubmed/24235144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.512186
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