Zinc Finger Nuclease Knock-out of NADPH:Cytochrome P450 Oxidoreductase (POR) in Human Tumor Cell Lines Demonstrates That Hypoxia-activated Prodrugs Differ in POR Dependence

Hypoxia, a ubiquitous feature of tumors, can be exploited by hypoxia-activated prodrugs (HAP) that are substrates for one-electron reduction in the absence of oxygen. NADPH:cytochrome P450 oxidoreductase (POR) is considered one of the major enzymes responsible, based on studies using purified enzyme...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Su, Jiechuang, Gu, Yongchuan, Pruijn, Frederik B., Smaill, Jeff B., Patterson, Adam V., Guise, Christopher P., Wilson, William R.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2013
Fag:
Enzymology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3873569/
https://ncbi.nlm.nih.gov/pubmed/24196959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.505222
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker