Zinc Finger Nuclease Knock-out of NADPH:Cytochrome P450 Oxidoreductase (POR) in Human Tumor Cell Lines Demonstrates That Hypoxia-activated Prodrugs Differ in POR Dependence

Hypoxia, a ubiquitous feature of tumors, can be exploited by hypoxia-activated prodrugs (HAP) that are substrates for one-electron reduction in the absence of oxygen. NADPH:cytochrome P450 oxidoreductase (POR) is considered one of the major enzymes responsible, based on studies using purified enzyme...

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Bibliographische Detailangaben
Hauptverfasser: Su, Jiechuang, Gu, Yongchuan, Pruijn, Frederik B., Smaill, Jeff B., Patterson, Adam V., Guise, Christopher P., Wilson, William R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2013
Schlagworte:
Enzymology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3873569/
https://ncbi.nlm.nih.gov/pubmed/24196959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.505222
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