Common Polymorphisms in Human Langerin Change Specificity for Glycan Ligands

Langerin, a C-type lectin on Langerhans cells, mediates carbohydrate-dependent uptake of pathogens in the first step of antigen presentation to the adaptive immune system. Langerin binds a diverse range of carbohydrates including high mannose structures, fucosylated blood group antigens, and glycans...

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Autors principals: Feinberg, Hadar, Rowntree, Thomas J. W., Tan, Shawn L. W., Drickamer, Kurt, Weis, William I., Taylor, Maureen E.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2013
Matèries:
Glycobiology and Extracellular Matrices
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3873535/
https://ncbi.nlm.nih.gov/pubmed/24217250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.528000
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