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A global suppressor motif for p53 cancer mutants

The transcription factor and tumor suppressor protein p53 is frequently inactivated in human cancers. In many cases, p53 gene mutations result in high levels of inactive, full-length p53 protein with one amino acid change in the core domain that recognizes p53 DNA-binding sites. The ability to endow...

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Salvato in:
Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Baroni, Timothy E., Wang, Ting, Qian, Hua, Dearth, Lawrence R., Truong, Lan N., Zeng, Jue, Denes, Alec E., Chen, Stephanie W., Brachmann, Rainer K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2004
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC387351/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15037740/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0401162101
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