Discovery and Preclinical Characterization of Novel Small Molecule TRK and ROS1 Tyrosine Kinase Inhibitors for the Treatment of Cancer and Inflammation

Receptor tyrosine kinases (RTKs), in response to their growth factor ligands, phosphorylate and activate downstream signals important for physiological development and pathological transformation. Increased expression, activating mutations and rearrangement fusions of RTKs lead to cancer, inflammati...

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Autori principali: Narayanan, Ramesh, Yepuru, Muralimohan, Coss, Christopher C., Wu, Zhongzhi, Bauler, Matthew N., Barrett, Christina M., Mohler, Michael L., Wang, Yun, Kim, Juhyun, Snyder, Linda M., He, Yali, Levy, Nelson, Miller, Duane D., Dalton, James T.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2013
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3873281/
https://ncbi.nlm.nih.gov/pubmed/24386191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0083380
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