Discovery and Preclinical Characterization of Novel Small Molecule TRK and ROS1 Tyrosine Kinase Inhibitors for the Treatment of Cancer and Inflammation

Receptor tyrosine kinases (RTKs), in response to their growth factor ligands, phosphorylate and activate downstream signals important for physiological development and pathological transformation. Increased expression, activating mutations and rearrangement fusions of RTKs lead to cancer, inflammati...

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Detalhes bibliográficos
Main Authors: Narayanan, Ramesh, Yepuru, Muralimohan, Coss, Christopher C., Wu, Zhongzhi, Bauler, Matthew N., Barrett, Christina M., Mohler, Michael L., Wang, Yun, Kim, Juhyun, Snyder, Linda M., He, Yali, Levy, Nelson, Miller, Duane D., Dalton, James T.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3873281/
https://ncbi.nlm.nih.gov/pubmed/24386191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0083380
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