Clearance of Alzheimer’s amyloid-β(1-40) peptide from brain by LDL receptor–related protein-1 at the blood-brain barrier

Elimination of amyloid-β peptide (Aβ) from the brain is poorly understood. After intracerebral microinjections in young mice, (125)I-Aβ(1-40) was rapidly removed from the brain (t(1/2) ≤ 25 minutes), mainly by vascular transport across the blood-brain barrier (BBB). The efflux transport system for A...

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Veröffentlicht in:	J Clin Invest
Hauptverfasser:	Shibata, Masayoshi, Yamada, Shinya, Kumar, S. Ram, Calero, Miguel, Bading, James, Frangione, Blas, Holtzman, David M., Miller, Carol A., Strickland, Dudley K., Ghiso, Jorge, Zlokovic, Berislav V.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Clinical Investigation 2000
Schlagworte:	Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC387254/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11120756/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI10498
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