Anti-malaria drug artesunate prevents development of amyloid-β pathology in mice by upregulating PICALM at the blood-brain barrier

Abstract Background PICALM is one of the most significant susceptibility factors for Alzheimer’s disease (AD). In humans and mice, PICALM is highly expressed in brain endothelium. PICALM endothelial levels are reduced in AD brains. PICALM controls several steps in Aβ transcytosis across the blood-br...

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Autori principali:	Kassandra Kisler, Abhay P. Sagare, Divna Lazic, Sam Bazzi, Erica Lawson, Ching-Ju Hsu, Yaoming Wang, Anita Ramanathan, Amy R. Nelson, Zhen Zhao, Berislav V. Zlokovic
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMC 2023-01-01
Serie:	Molecular Neurodegeneration
Soggetti:	Artesunate PICALM Blood-brain barrier Alzheimer’s disease Amyloid-β Mice
Accesso online:	https://doi.org/10.1186/s13024-023-00597-5
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