Anti-malaria drug artesunate prevents development of amyloid-β pathology in mice by upregulating PICALM at the blood-brain barrier

Abstract Background PICALM is one of the most significant susceptibility factors for Alzheimer’s disease (AD). In humans and mice, PICALM is highly expressed in brain endothelium. PICALM endothelial levels are reduced in AD brains. PICALM controls several steps in Aβ transcytosis across the blood-br...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Kassandra Kisler, Abhay P. Sagare, Divna Lazic, Sam Bazzi, Erica Lawson, Ching-Ju Hsu, Yaoming Wang, Anita Ramanathan, Amy R. Nelson, Zhen Zhao, Berislav V. Zlokovic
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2023-01-01
coleção:	Molecular Neurodegeneration
Assuntos:	Artesunate PICALM Blood-brain barrier Alzheimer’s disease Amyloid-β Mice
Acesso em linha:	https://doi.org/10.1186/s13024-023-00597-5
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!