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Clearance of Alzheimer’s amyloid-β(1-40) peptide from brain by LDL receptor–related protein-1 at the blood-brain barrier
Elimination of amyloid-β peptide (Aβ) from the brain is poorly understood. After intracerebral microinjections in young mice, (125)I-Aβ(1-40) was rapidly removed from the brain (t(1/2) ≤ 25 minutes), mainly by vascular transport across the blood-brain barrier (BBB). The efflux transport system for A...
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| Autori principali: | , , , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Clinical Investigation
2000
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC387254/ https://ncbi.nlm.nih.gov/pubmed/11120756 |
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