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TRAF5 negatively regulates Toll-like receptor signaling in B lymphocytes

The cytoplasmic adaptor proteins TNF receptor associated factor (TRAF)3 and TRAF6 are important mediators of TLR signaling. We show here for the first time that another TRAF family member, TRAF5, is a negative regulator of TLR signaling. B lymphocytes from TRAF5(−/−) mice produced more IL-6, IL-12p4...

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Detalhes bibliográficos
Main Authors: Buchta, Claire M, Bishop, Gail A
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3872259/
https://ncbi.nlm.nih.gov/pubmed/24259503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1301901
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