Correction of hypophosphatasia (HPP) associated mineralization deficiencies in vitro by phosphate/pyrophosphate modulation in periodontal ligament cells

BACKGROUND: Mutations in the Alpl gene in hypophosphatasia (HPP) reduce the function of tissue nonspecific alkaline phosphatase (TNAP), resulting in increased pyrophosphate (PP(i)) and a severe deficiency in acellular cementum. We hypothesized that exogenous phosphate (P(i)) would rescue the in vitr...

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Main Authors: Rodrigues, Thaisângela L., Foster, Brian L., Silverio, Karina G., Martins, Luciane, Casati, Marcio Z., Sallum, Enilson A., Somerman, Martha J., Nociti, Francisco H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3871996/
https://ncbi.nlm.nih.gov/pubmed/22014174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1902/jop.2011.110310
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