Correction of hypophosphatasia (HPP) associated mineralization deficiencies in vitro by phosphate/pyrophosphate modulation in periodontal ligament cells

BACKGROUND: Mutations in the Alpl gene in hypophosphatasia (HPP) reduce the function of tissue nonspecific alkaline phosphatase (TNAP), resulting in increased pyrophosphate (PP(i)) and a severe deficiency in acellular cementum. We hypothesized that exogenous phosphate (P(i)) would rescue the in vitr...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Rodrigues, Thaisângela L., Foster, Brian L., Silverio, Karina G., Martins, Luciane, Casati, Marcio Z., Sallum, Enilson A., Somerman, Martha J., Nociti, Francisco H.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2011
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3871996/
https://ncbi.nlm.nih.gov/pubmed/22014174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1902/jop.2011.110310
Etiketak: Etiketa erantsi
Etiketarik gabe, Izan zaitez lehena erregistro honi etiketa jartzen!

Antzeko izenburuak