Correction of hypophosphatasia (HPP) associated mineralization deficiencies in vitro by phosphate/pyrophosphate modulation in periodontal ligament cells

BACKGROUND: Mutations in the Alpl gene in hypophosphatasia (HPP) reduce the function of tissue nonspecific alkaline phosphatase (TNAP), resulting in increased pyrophosphate (PP(i)) and a severe deficiency in acellular cementum. We hypothesized that exogenous phosphate (P(i)) would rescue the in vitr...

Ful tanımlama

Kaydedildi:
Detaylı Bibliyografya
Asıl Yazarlar: Rodrigues, Thaisângela L., Foster, Brian L., Silverio, Karina G., Martins, Luciane, Casati, Marcio Z., Sallum, Enilson A., Somerman, Martha J., Nociti, Francisco H.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2011
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3871996/
https://ncbi.nlm.nih.gov/pubmed/22014174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1902/jop.2011.110310
Etiketler: Etiketle
Etiket eklenmemiş, İlk siz ekleyin!

Benzer Materyaller