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Correction of hypophosphatasia (HPP) associated mineralization deficiencies in vitro by phosphate/pyrophosphate modulation in periodontal ligament cells
BACKGROUND: Mutations in the Alpl gene in hypophosphatasia (HPP) reduce the function of tissue nonspecific alkaline phosphatase (TNAP), resulting in increased pyrophosphate (PP(i)) and a severe deficiency in acellular cementum. We hypothesized that exogenous phosphate (P(i)) would rescue the in vitr...
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| 主要な著者: | , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2011
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3871996/ https://ncbi.nlm.nih.gov/pubmed/22014174 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1902/jop.2011.110310 |
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