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Role of CYP2A13 in the bioactivation and lung tumorigenicity of the tobacco-specific lung procarcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone: in vivo studies using a CYP2A13-humanized mouse model

The tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), which is abundant in tobacco smoke, is a potent lung procarcinogen. The present study was aimed to prove that transgenic expression of human cytochrome P450 2A13 (CYP2A13), known to be selectively expressed in the...

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Autori principali: Megaraj, Vandana, Zhou, Xin, Xie, Fang, Liu, Zhihua, Yang, Weizhu, Ding, Xinxin
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3871935/
https://ncbi.nlm.nih.gov/pubmed/23917075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgt269
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