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Antibody conjugation via one and two C-terminal selenocysteines
Conventional antibody conjugation methods generate antibody-drug conjugates that are heterogeneous mixtures with undefined stoichiometry and variable pharmacokinetic and pharmacodynamic properties. We have previously described a strategy to generate site-specific antibody conjugates by genetic engin...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3871924/ https://ncbi.nlm.nih.gov/pubmed/23756202 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymeth.2013.05.023 |
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