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Assessment of Reagents for Selenocysteine Conjugation and the Stability of Selenocysteine Adducts
Conventional antibody-drug conjugates (ADCs) are heterogeneous mixtures that have poor pharmacokinetic properties and decreased efficacy relative to homogenous ADCs. Furthermore, ADCs that are maleimide-based often have inadequate circulatory stability, which can result in premature drug release wit...
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| Publicado no: | Org Biomol Chem |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4887430/ https://ncbi.nlm.nih.gov/pubmed/27184239 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c6ob00775a |
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