Sustained Delivery of a HIF-1 Antagonist for Ocular Neovascularization

Doxorubicin (DXR) and daunorubicin (DNR) inhibit hypoxia-inducible factor-1 (HIF-1) transcriptional activity by blocking its binding to DNA. Intraocular injections of DXR or DNR suppressed choroidal and retinal neovascularization (NV), but also perturbed retinal function as demonstrated by electrore...

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Main Authors: Iwase, Takeshi, Fu, Jie, Yoshida, Tsunehiko, Muramatsu, Daisuke, Miki, Akiko, Hashida, Noriyasu, Lu, Lili, Oveson, Brian, Silva, Raquel Lima e, Seidel, Christopher, Yang, Ming, Connelly, Sheila, Shen, Jikui, Han, Bing, Wu, Mingsheng, Semenza, Gregg L., Hanes, Justin, Campochiaro, Peter A.
Format: Artigo
Language:Inglês
Published: 2013
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3871855/
https://ncbi.nlm.nih.gov/pubmed/24126220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2013.10.008
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