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Hemoglobin S Antilles: a variant with lower solubility than hemoglobin S and producing sickle cell disease in heterozygotes.

We have found a sickling variant, Hb S Antilles, alpha 2 beta 2(6 Glu----Val, 23 Val----Ile), that has the same electrophoretic mobility as Hb S but a distinct isoelectric focus and produces sickling in the carriers of the Hb A/S Antilles trait. The carriers' erythrocytes tend to sickle at O2 partia...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Monplaisir, N, Merault, G, Poyart, C, Rhoda, M D, Craescu, C, Vidaud, M, Galacteros, F, Blouquit, Y, Rosa, J
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1986
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC387138/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3467311/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.83.24.9363
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