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MYC-driven accumulation of 2-hydroxyglutarate is associated with breast cancer prognosis

Metabolic profiling of cancer cells has recently been established as a promising tool for the development of therapies and identification of cancer biomarkers. Here we characterized the metabolomic profile of human breast tumors and uncovered intrinsic metabolite signatures in these tumors using an...

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Autors principals: Terunuma, Atsushi, Putluri, Nagireddy, Mishra, Prachi, Mathé, Ewy A., Dorsey, Tiffany H., Yi, Ming, Wallace, Tiffany A., Issaq, Haleem J., Zhou, Ming, Killian, J. Keith, Stevenson, Holly S., Karoly, Edward D., Chan, King, Samanta, Susmita, Prieto, DaRue, Hsu, Tiffany Y.T., Kurley, Sarah J., Putluri, Vasanta, Sonavane, Rajni, Edelman, Daniel C., Wulff, Jacob, Starks, Adrienne M., Yang, Yinmeng, Kittles, Rick A., Yfantis, Harry G., Lee, Dong H., Ioffe, Olga B., Schiff, Rachel, Stephens, Robert M., Meltzer, Paul S., Veenstra, Timothy D., Westbrook, Thomas F., Sreekumar, Arun, Ambs, Stefan
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2013
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3871244/
https://ncbi.nlm.nih.gov/pubmed/24316975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI71180
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