Therapeutic antagonists of microRNAs deplete leukemia-initiating cell activity

Acute myelogenous leukemia (AML) subtypes that result from oncogenic activation of homeobox (HOX) transcription factors are associated with poor prognosis. The HOXA9 transcription activator and growth factor independent 1 (GFI1) transcriptional repressor compete for occupancy at DNA-binding sites fo...

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Detalhes bibliográficos
Main Authors: Velu, Chinavenmeni S., Chaubey, Aditya, Phelan, James D., Horman, Shane R., Wunderlich, Mark, Guzman, Monica L., Jegga, Anil G., Zeleznik-Le, Nancy J., Chen, Jianjun, Mulloy, James C., Cancelas, Jose A., Jordan, Craig T., Aronow, Bruce J., Marcucci, Guido, Bhat, Balkrishen, Gebelein, Brian, Grimes, H. Leighton
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3871218/
https://ncbi.nlm.nih.gov/pubmed/24334453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI66005
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