Therapeutic antagonists of microRNAs deplete leukemia-initiating cell activity

Acute myelogenous leukemia (AML) subtypes that result from oncogenic activation of homeobox (HOX) transcription factors are associated with poor prognosis. The HOXA9 transcription activator and growth factor independent 1 (GFI1) transcriptional repressor compete for occupancy at DNA-binding sites fo...

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Hlavní autoři: Velu, Chinavenmeni S., Chaubey, Aditya, Phelan, James D., Horman, Shane R., Wunderlich, Mark, Guzman, Monica L., Jegga, Anil G., Zeleznik-Le, Nancy J., Chen, Jianjun, Mulloy, James C., Cancelas, Jose A., Jordan, Craig T., Aronow, Bruce J., Marcucci, Guido, Bhat, Balkrishen, Gebelein, Brian, Grimes, H. Leighton
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2013
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3871218/
https://ncbi.nlm.nih.gov/pubmed/24334453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI66005
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