Gfi1 integrates progenitor versus granulocytic transcriptional programming

In patients with severe congenital neutropenia (SCN) and mice with growth factor independent-1 (Gfi1) loss of function, arrested myeloid progenitors accumulate, whereas terminal granulopoiesis is blocked. One might assume that Gfi-null progenitors accumulate because they lack the ability to differen...

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Autors principals: Horman, Shane R., Velu, Chinavenmeni S., Chaubey, Aditya, Bourdeau, Tristan, Zhu, Jinfang, Paul, William E., Gebelein, Brian, Grimes, H. Leighton
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2009
Matèries:
Hematopoiesis and Stem Cells
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2689047/
https://ncbi.nlm.nih.gov/pubmed/19346496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-09-179747
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