Characterization of the interaction between Robo1 and heparin and other glycosaminoglycans

Roundabout 1 (Robo1) is the cognate receptor for secreted axon guidance molecule, Slits, which function to direct cellular migration during neuronal development and angiogenesis. The Slit2–Robo1 signaling is modulated by heparan sulfate, a sulfated linear polysaccharide that is abundantly expressed...

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Main Authors: Zhang, Fuming, Moniz, Heather A., Walcott, Benjamin, Moremen, Kelley W., Linhardt, Robert J., Wang, Lianchun
Format: Artigo
Jezik:Inglês
Izdano: 2013
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3871176/
https://ncbi.nlm.nih.gov/pubmed/23994753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biochi.2013.08.018
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