Jimpy mutant mouse: a 74-base deletion in the mRNA for myelin proteolipid protein and evidence for a primary defect in RNA splicing.

The mouse mutant jimpy carries an X chromosome-linked recessive gene defect that affects the formation of myelin in the central nervous system. To understand the molecular basis of the jimpy mutation, we have examined the expression of mRNAs encoding myelin proteolipid protein (PLP). PLP mRNAs were...

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Publicado en:	Proc Natl Acad Sci U S A
Autores principales:	Nave, K A, Lai, C, Bloom, F E, Milner, R J
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	National Academy of Sciences 1986
Materias:	Research Article
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC387116/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3466187/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.83.23.9264
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