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Jimpy mutant mouse: a 74-base deletion in the mRNA for myelin proteolipid protein and evidence for a primary defect in RNA splicing.

The mouse mutant jimpy carries an X chromosome-linked recessive gene defect that affects the formation of myelin in the central nervous system. To understand the molecular basis of the jimpy mutation, we have examined the expression of mRNAs encoding myelin proteolipid protein (PLP). PLP mRNAs were...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Nave, K A, Lai, C, Bloom, F E, Milner, R J
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1986
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC387116/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3466187/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.83.23.9264
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