The mTORC1/mTORC2 inhibitor AZD2014 enhances the radiosensitivity of glioblastoma stem-like cells

BACKGROUND: The mammalian target of rapamycin (mTOR) has been suggested as a target for radiosensitization. Given that radiotherapy is a primary treatment modality for glioblastoma (GBM) and that mTOR is often dysregulated in GBM, the goal of this study was to determine the effects of AZD2014, a dua...

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Bibliografiske detaljer
Main Authors: Kahn, Jenna, Hayman, Thomas J., Jamal, Muhammad, Rath, Barbara H., Kramp, Tamalee, Camphausen, Kevin, Tofilon, Philip J.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2014
Fag:
Basic and Translational Investigations
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3870843/
https://ncbi.nlm.nih.gov/pubmed/24311635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/not139
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