Antidepressant-Like Properties of Novel HDAC6-Selective Inhibitors with Improved Brain Bioavailability

HDAC inhibitors have been reported to produce antidepressant and pro-cognitive effects in animal models, however, poor brain bioavailability or lack of isoform selectivity of current probes has limited our understanding of their mode of action. We report the characterization of novel pyrimidine hydr...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Jochems, Jeanine, Boulden, Janette, Lee, Bridgin G, Blendy, Julie A, Jarpe, Matthew, Mazitschek, Ralph, Van Duzer, John H, Jones, Simon, Berton, Olivier
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3870780/
https://ncbi.nlm.nih.gov/pubmed/23954848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2013.207
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados