Antidepressant-Like Properties of Novel HDAC6-Selective Inhibitors with Improved Brain Bioavailability

HDAC inhibitors have been reported to produce antidepressant and pro-cognitive effects in animal models, however, poor brain bioavailability or lack of isoform selectivity of current probes has limited our understanding of their mode of action. We report the characterization of novel pyrimidine hydr...

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Autors principals: Jochems, Jeanine, Boulden, Janette, Lee, Bridgin G, Blendy, Julie A, Jarpe, Matthew, Mazitschek, Ralph, Van Duzer, John H, Jones, Simon, Berton, Olivier
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2014
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3870780/
https://ncbi.nlm.nih.gov/pubmed/23954848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2013.207
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