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Rewriting the rules for end joining via enzymatic splicing of DNA 3′-PO(4) and 5′-OH ends
There are many biological contexts in which DNA damage generates “dirty” breaks with 3′-PO(4) (or cyclic-PO(4)) and 5′-OH ends that cannot be sealed by DNA ligases. Here we show that the Escherichia coli RNA ligase RtcB can splice these dirty DNA ends via a unique chemical mechanism. RtcB transfers...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3870732/ https://ncbi.nlm.nih.gov/pubmed/24218597 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1314289110 |
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