Codon 104 variation of p53 gene provides adaptive apoptotic responses to extreme environments in mammals of the Tibet plateau

Mutational changes in p53 correlate well with tumorigenesis. Remarkably, however, relatively little is known about the role that p53 variations may play in environmental adaptation. Here we report that codon asparagine-104 (104N) and glutamic acid-104 (104E), respectively, of the p53 gene in the wil...

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Detalhes bibliográficos
Main Authors: Zhao, Yang, Ren, Ji-Long, Wang, Ming-Yang, Zhang, Sheng-Ting, Liu, Yu, Li, Min, Cao, Yi-Bin, Zu, Hu-Yue, Chen, Xiao-Cheng, Wu, Chung-I, Nevo, Eviatar, Chen, Xue-Qun, Du, Ji-Zeng
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3870672/
https://ncbi.nlm.nih.gov/pubmed/24297887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1320369110
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