HIV-1 gp120 impairs B cell proliferation by inducing TGF-β1 production and FcRL4 expression

The humoral immune response following acute HIV-1 infection is delayed and ineffective. The HIV-1 envelope protein gp120 binds to and signals through α(4)β(7) on T cells. We show that gp120 also binds and signals through α(4)β(7) on naïve B cells, resulting in an abortive proliferative response. In...

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Main Authors: Jelicic, Katija, Cimbro, Raffaello, Nawaz, Fatima, Huang, Da Wei, Zheng, Xin, Yang, Jun, Lempicki, Richard A., Pascuccio, Massimiliano, Van Ryk, Donald, Schwing, Catherine, Hiatt, Joseph, Okwara, Noreen, Wei, Danlan, Roby, Gregg, David, Antonio, Hwang, Young, Kehrl, John H., Arthos, James, Cicala, Claudia, Fauci, Anthony S.
Formato: Artigo
Idioma:Inglês
Publicado: 2013
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3870659/
https://ncbi.nlm.nih.gov/pubmed/24162774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.2746
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