Effects of genetic variation at the CYP2C19/CYP2C9 locus on pharmacokinetics of chlorcycloguanil in adult Gambians

AIMS: Antimalarial biguanides are metabolized by CYP2C19, thus genetic variation at the CYP2C locus might affect pharmacokinetics and so treatment outcome for malaria. MATERIALS & METHODS: Polymorphisms in CYP2C19 and CYP2C9 in 43 adult Gambians treated with chlorproguanil/dapsone for uncomplica...

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Detalhes bibliográficos
Main Authors: Janha, Ramatoulie E, Sisay-Joof, Fatoumatta, Hamid-Adiamoh, Majidah, Worwui, Archibald, Chapman, Hannah L, Opara, Hyginus, Dunyo, Sam, Milligan, Paul, Rockett, Kirk, Winstanley, Peter, Pirmohamed, Munir, Miller, Ann K, Conway, David J, Walton, Robert T
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3870622/
https://ncbi.nlm.nih.gov/pubmed/19761366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2217/pgs.09.72
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