Inactive alleles of cytochrome P450 2C19 may be positively selected in human evolution

BACKGROUND: Cytochrome P450 CYP2C19 metabolizes a wide range of pharmacologically active substances and a relatively small number of naturally occurring environmental toxins. Poor activity alleles of CYP2C19 are very frequent worldwide, particularly in Asia, raising the possibility that reduced meta...

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Bibliografiske detaljer
Main Authors: Janha, Ramatoulie E, Worwui, Archibald, Linton, Kenneth J, Shaheen, Seif O, Sisay-Joof, Fatoumatta, Walton, Robert T
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2014
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4036532/
https://ncbi.nlm.nih.gov/pubmed/24690327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2148-14-71
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