Cyanobacterial polyketide synthase docking domains, a new tool for engineering natural product biosynthesis

Modular type I polyketide synthases (PKSs) are versatile biosynthetic systems that initiate, successively elongate and modify acyl chains. Intermediate transfer between modules is mediated via docking domains, which are attractive targets for PKS pathway engineering to produce novel small molecules....

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Autors principals: Whicher, Jonathan R., Smaga, Sarah S., Hansen, Douglas A., Brown, William C., Gerwick, William H., Sherman, David H., Smith, Janet L.
Format: Artigo
Idioma:Inglês
Publicat: 2013
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3870462/
https://ncbi.nlm.nih.gov/pubmed/24183970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2013.09.015
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