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The Helical Alanine Controversy: An (Ala)(6) Insertion Dramatically Increases Helicity
Employing chemical shift melts and hydrogen/deuterium exchange NMR techniques, we have determined the stabilization of the Trp-cage miniprotein due to multiple alanine insertions within the N-terminal α-helix. Alanine is shown to be uniquely helix-stabilizing and this stabilization is reflected in t...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2004
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3870188/ https://ncbi.nlm.nih.gov/pubmed/15493925 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja047265o |
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