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The Trp-cage: optimizing the stability of a globular miniprotein
The Trp-cage, as the smallest miniprotein, remains the subject of numerous computational and experimental studies of protein folding dynamics and pathways. The original Trp-cage (NLYIQWLKDGGPSSGRPPPS, Tm = 42°C) can be significantly stabilized by mutations; melting points as high as 64°C are reporte...
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| Hauptverfasser: | , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2008
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3166533/ https://ncbi.nlm.nih.gov/pubmed/18203802 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/protein/gzm082 |
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