Paired immunoglobulin-like receptor A is an intrinsic, self-limiting suppressor of IL-5-induced eosinophil development

Eosinophilia is a hallmark characteristic of T(H)2-associated diseases and is critically regulated by the central eosinophil growth factor interleukin 5 (IL-5). Here we demonstrate that IL-5 activity in eosinophils was regulated by paired immunoglobulin-like receptor (PIR)-A and PIR-B. Upon self-rec...

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Bibliografiske detaljer
Main Authors: Baruch-Morgenstern, Netali Ben, Shik, Dana, Moshkovits, Itay, Itan, Michal, Karo-Atar, Danielle, Bouffi, Carine, Fulkerson, Patricia, Rashkovan, Diana, Jung, Steffen, Rothenberg, Marc E., Munitz, Ariel
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3869881/
https://ncbi.nlm.nih.gov/pubmed/24212998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.2757
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