Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death

Brugada syndrome is a rare cardiac arrhythmia disorder, causally related to SCN5A mutations in around 20% of cases(1–3). Through a genome-wide association study of 312 individuals with Brugada syndrome and 1,115 controls, we detected 2 significant association signals at the SCN10A locus (rs10428132)...

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Main Authors: Bezzina, Connie R., Barc, Julien, Mizusawa, Yuka, Remme, Carol Ann, Gourraud, Jean-Baptiste, Simonet, Floriane, Verkerk, Arie O., Schwartz, Peter J., Crotti, Lia, Dagradi, Federica, Guicheney, Pascale, Fressart, Véronique, Leenhardt, Antoine, Antzelevitch, Charles, Bartkowiak, Susan, Schulze-Bahr, Eric, Zumhagen, Sven, Behr, Elijah R., Bastiaenen, Rachel, Tfelt-Hansen, Jacob, Olesen, Morten Salling, Kääb, Stefan, Beckmann, Britt M., Weeke, Peter, Watanabe, Hiroshi, Endo, Naoto, Minamino, Tohru, Horie, Minoru, Ohno, Seiko, Hasegawa, Kanae, Makita, Naomasa, Nogami, Akihiko, Shimizu, Wataru, Aiba, Takeshi, Froguel, Philippe, Balkau, Beverley, Lantieri, Olivier, Torchio, Margherita, Wiese, Cornelia, Weber, David, Wolswinkel, Rianne, Coronel, Ruben, Boukens, Bas J., Bézieau, Stéphane, Charpentier, Eric, Chatel, Stéphanie, Despres, Aurore, Gros, Françoise, Kyndt, Florence, Lecointe, Simon, Lindenbaum, Pierre, Portero, Vincent, Violleau, Jade, Gessler, Manfred, Tan, Hanno L., Roden, Dan M., Christoffels, Vincent M., Le Marec, Hervé, Wilde, Arthur A, Probst, Vincent, Schott, Jean-Jacques, Dina, Christian, Redon, Richard
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3869788/
https://ncbi.nlm.nih.gov/pubmed/23872634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.2712
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