Antibody–peptide–MHC fusion conjugates target non-cognate T cells to kill tumour cells

Attempts to generate robust anti-tumour cytotoxic T lymphocyte (CTL) responses using immunotherapy are frequently thwarted by exhaustion and anergy of CTL recruited to tumour. One strategy to overcome this is to retarget a population of virus-specific CTL to kill tumour cells. Here, we describe a pr...

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Detalhes bibliográficos
Main Authors: King, Ben C., Hamblin, Angela D., Savage, Philip M., Douglas, Leon R., Hansen, Ted H., French, Ruth R., Johnson, Peter W. M., Glennie, Martin J.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer-Verlag 2013
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3869625/
https://ncbi.nlm.nih.gov/pubmed/23604105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00262-013-1408-8
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