A Rev-Independent gag/pol Eliminates Detectable psi-gag Recombination in Lentiviral Vectors

Lentiviral vectors (LVs) are being developed for clinical use in humans for applications including gene therapy and immunotherapy. A safety concern for use of LVs in humans is the generation of replication-competent lentivirus (RCL), which may arise due to recombination between the split genomes of...

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Autors principals: Tareen, Semih U., Nicolai, Christopher J., Campbell, David J., Flynn, Patrick A., Slough, Megan M., Vin, Chintan D., Kelley-Clarke, Brenna, Odegard, Jared M., Robbins, Scott H.
Format: Artigo
Idioma:Inglês
Publicat: Mary Ann Liebert, Inc. 2013
Matèries:
Original Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3869434/
https://ncbi.nlm.nih.gov/pubmed/24380052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/biores.2013.0037
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