Variants in two adjacent genes, EGLN2 and CYP2A6, influence smoking behavior related to disease risk via different mechanisms

Genome-wide significant associations with cigarettes per day (CPD) and risk for lung cancer and chronic obstructive pulmonary disease (COPD) were previously reported in a region of 19q13, including CYP2A6 (nicotine metabolism enzyme) and EGLN2 (hypoxia response). The associated single nucleotide pol...

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Главные авторы: Bloom, A. Joseph, Baker, Timothy B., Chen, Li-Shiun, Breslau, Naomi, Hatsukami, Dorothy, Bierut, Laura J., Goate, Alison
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2014
Предметы:
Association Studies Articles
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3869360/
https://ncbi.nlm.nih.gov/pubmed/24045616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddt432
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