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Formation of muconaldehyde, an open-ring metabolite of benzene, in mouse liver microsomes: an additional pathway for toxic metabolites.

It has been proposed that a ring-opened form may be responsible for the toxicity of benzene. The present studies demonstrate that incubation of [14C]benzene with liver microsomes (obtained from male CD-1 mice treated with benzene) in the presence of NADPH results in the formation of a ring-opened pr...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Proc Natl Acad Sci U S A
Prif Awduron: Latriano, L, Goldstein, B D, Witz, G
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 1986
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC386927/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3464956/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.83.21.8356
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