Endocytic Profiles of δ-Opioid Receptor Ligands Determine the Duration of Rapid but Not Sustained cAMP Responses

Traditional assays that monitor cAMP inhibition by opioid receptor ligands require second-messenger accumulation over periods of 10–20 minutes. Since receptor regulation occurs within a similar time frame, such assays do not discriminate the actual signal from its modulation. Here we used biolumines...

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Hauptverfasser: Tudashki, Hanieh Bagheri, Robertson, Derek N., Schiller, Peter W., Pineyro, Graciela
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Pharmacology and Experimental Therapeutics 2014
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3868905/
https://ncbi.nlm.nih.gov/pubmed/24174495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.113.089003
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