FK506-Binding Protein 12 Modulates μ-Opioid Receptor Phosphorylation and Protein Kinase Cε–Dependent Signaling by Its Direct Interaction with the Receptor

Protein kinase C (PKC) activation plays an important role in morphine-induced μ-opioid receptor (OPRM1) desensitization and tolerance development. It was recently shown that receptor phosphorylation by G protein–coupled receptor kinase regulates agonist-dependent selective signaling and that ineffic...

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Hlavní autoři: Qiu, Yu, Zhao, Wei, Wang, Yan, Xu, Jian-Rong, Huie, Eddie, Jiang, Shan, Yan, Ying-Hui, Loh, Horace H., Chen, Hong-Zhuan, Law, Ping-Yee
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society for Pharmacology and Experimental Therapeutics 2014
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3868904/
https://ncbi.nlm.nih.gov/pubmed/24113748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.113.087825
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