Transient Receptor Potential Channel 6 (TRPC6) Protects Podocytes during Complement-mediated Glomerular Disease

Gain-of-function mutations in the calcium channel TRPC6 lead to autosomal dominant focal segmental glomerulosclerosis and podocyte expression of TRPC6 is increased in some acquired human glomerular diseases, particularly in membranous nephropathy. These observations led to the hypothesis that TRPC6...

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Hlavní autoři: Kistler, Andreas D., Singh, Geetika, Altintas, Mehmet M., Yu, Hao, Fernandez, Isabel C., Gu, Changkyu, Wilson, Cory, Srivastava, Sandeep Kumar, Dietrich, Alexander, Walz, Katherina, Kerjaschki, Dontscho, Ruiz, Phillip, Dryer, Stuart, Sever, Sanja, Dinda, Amit K., Faul, Christian, Reiser, Jochen
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2013
Témata:
Signal Transduction
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3868772/
https://ncbi.nlm.nih.gov/pubmed/24194522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.488122
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