Transient Receptor Potential Channel 6 (TRPC6) Protects Podocytes during Complement-mediated Glomerular Disease

Gain-of-function mutations in the calcium channel TRPC6 lead to autosomal dominant focal segmental glomerulosclerosis and podocyte expression of TRPC6 is increased in some acquired human glomerular diseases, particularly in membranous nephropathy. These observations led to the hypothesis that TRPC6...

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Main Authors: Kistler, Andreas D., Singh, Geetika, Altintas, Mehmet M., Yu, Hao, Fernandez, Isabel C., Gu, Changkyu, Wilson, Cory, Srivastava, Sandeep Kumar, Dietrich, Alexander, Walz, Katherina, Kerjaschki, Dontscho, Ruiz, Phillip, Dryer, Stuart, Sever, Sanja, Dinda, Amit K., Faul, Christian, Reiser, Jochen
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Signal Transduction
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3868772/
https://ncbi.nlm.nih.gov/pubmed/24194522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.488122
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